Introduction Retinoblastoma is a rare eye tumor of childhood that arises in the retina and represents the most common intraocular malignancy of infancy and childhood [ a ]. It may occur at any age but most often it occurs in younger children, usually before the age of two years. His prognosis is good since over 95% of children are cured in industrialized countries. Retinoblastoma is the most common intraocular tumor of the child; its incidence is stable, described around 1/15 000 to 1/20 000 births. It is unilateral in 60% of patients, with a median age at the time of diagnosis of 2 years old. It is bilateral in 40% of patients: the median age at the time of diagnosis is then about 1 year and tends to decline in industrialized countries through screening of children at risk in the neonatal period. Factors of infectious or environmental risks favoring the occurrence retinoblastoma have been reported but can not be today considered established [3,4]. The occurrence more frequent retino