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Showing posts from February, 2022

Vaccine efficacy and iron deficiency: an intertwined pair

Vaccine efficacy and iron deficiency: an intertwined pair? Hal Drakesmith, Sant-Rayn Pasricha, Ioav Cabantchik, Chaim Hershko, Guenter Weiss, Domenico Girelli, Nicole Stoffel, Martina U Muckenthaler, Elizabeta Nemeth, Clara Camaschella, Paul Klenerman, Michael B Zimmermann Vaccines are the most effective measure to prevent deaths and illness from infectious diseases. Nevertheless, the efficacy of several paediatric vaccines is lower in low-income and middle-income countries (LMICs), where mortality from vaccine-preventable infections remains high. Vaccine efficacy can also be decreased in adults in the context of some common comorbidities. Identifying and correcting the specific causes of impaired vaccine efficacy is of substantial value to global health. Iron deficiency is the most common micronutrient deficiency worldwide, affecting more than 2 billion people, and its prevalence in LMICs could increase as food security is threatened by the COVID-19 pandemic. In this Viewpoint, we hig

Pineal region pilocytic astrocytoma; an unusual tumor: A cases report

  Dr. Ashis Kumar Ghosh Cancer/Oncology specialist Assistant Professor Department of Pediatric Hematology and Oncology National Institute of Cancer Research and Hospital Expertise:  Pediatric Hematology, Pediatric Oncology, Rare Childhood Cancer and Pediatric Medicine Tel- 01712685509 Pineal region tumors account for <1% of all intracranial neoplasms, of which approximately 14–27% is of pineal parenchymal origin.[ 1 ] Gliomas are very rare in the pineal region. They are thought to arise from the native glial cells of pineal gland or from the adjacent structure.[ 2 ] A wide spectrum of pineal region glial tumors have been described including pilocytic astrocytoma (PA), pleomorphic xanthoastrocytoma, glioblastoma, oligodendroglioma, and ganglioglioma; mainly as case reports. We report one cases of pineal region PA with variable clinical, radiological, and histological features with a review of literature. Case 1: An 8-year-old male child was brought to the Pediatric Hematology and Onc